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{"slip": { "id": 72, "advice": "Don't eat anything your grandparents wouldn't recognise as food."}}
{"slip": { "id": 45, "advice": "Build something out of LEGO."}}
{"type":"standard","title":"MARCO","displaytitle":"MARCO","namespace":{"id":0,"text":""},"wikibase_item":"Q18033213","titles":{"canonical":"MARCO","normalized":"MARCO","display":"MARCO"},"pageid":14882018,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/330px-Ideogram_human_chromosome_2.svg.png","width":320,"height":128},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/474px-Ideogram_human_chromosome_2.svg.png","width":474,"height":189},"lang":"en","dir":"ltr","revision":"1279715953","tid":"794613a9-fd63-11ef-8d03-03c5d7ee57db","timestamp":"2025-03-10T03:55:15Z","description":"Protein-coding gene in the species Homo sapiens","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/MARCO","revisions":"https://en.wikipedia.org/wiki/MARCO?action=history","edit":"https://en.wikipedia.org/wiki/MARCO?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:MARCO"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/MARCO","revisions":"https://en.m.wikipedia.org/wiki/Special:History/MARCO","edit":"https://en.m.wikipedia.org/wiki/MARCO?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:MARCO"}},"extract":"Macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene. MARCO is a class A scavenger receptor that is found on particular subsets of macrophages. Scavenger receptors are pattern recognition receptors (PRRs) found most commonly on immune cells. Their defining feature is that they bind to polyanions and modified forms of a type of cholesterol called low-density lipoprotein (LDL). MARCO is able to bind and phagocytose these ligands and pathogen-associated molecular patterns (PAMPs), leading to the clearance of pathogens and cell signaling events that lead to inflammation. As part of the innate immune system, MARCO clears, or scavenges, pathogens, which leads to inflammatory responses. The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO binds ligands to activate the subsequent immune responses. MARCO expression on macrophages has been associated with tumor development and also with Alzheimer's disease, via decreased responses of cells when ligands bind to MARCO.","extract_html":"
Macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene. MARCO is a class A scavenger receptor that is found on particular subsets of macrophages. Scavenger receptors are pattern recognition receptors (PRRs) found most commonly on immune cells. Their defining feature is that they bind to polyanions and modified forms of a type of cholesterol called low-density lipoprotein (LDL). MARCO is able to bind and phagocytose these ligands and pathogen-associated molecular patterns (PAMPs), leading to the clearance of pathogens and cell signaling events that lead to inflammation. As part of the innate immune system, MARCO clears, or scavenges, pathogens, which leads to inflammatory responses. The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO binds ligands to activate the subsequent immune responses. MARCO expression on macrophages has been associated with tumor development and also with Alzheimer's disease, via decreased responses of cells when ligands bind to MARCO.
"}{"fact":"A cat's whiskers are thought to be a kind of radar, which helps a cat gauge the space it intends to walk through.","length":113}
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{"slip": { "id": 1, "advice": "Remember that spiders are more afraid of you, than you are of them."}}
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{"fact":"Fossil records from two million years ago show evidence of jaguars.","length":67}
{"slip": { "id": 3, "advice": "Don't eat non-snow-coloured snow."}}